Preparation of Inhalable Valsartan Nanosuspension and Its Application in the Treatment of Chronic Obstructive Pulmonary Disease
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Abstract
To enhance the bioavailability and targeting efficiency of valsartan for local treatment of chronic obstructive pulmonary disease (COPD), a nanosuspension with uniform particle size was prepared using the wet milling method. The storage stability of the formulation was further improved through lyophilization. In addition, the diffusion behavior of the nanoparticles in airway mucus was optimized by adjusting the osmotic pressure of the inhalation carrier. An intratracheal administration model in mice was employed to evaluate the pharmacokinetic characteristics and therapeutic efficacy of the formulation. The results showed that the prepared nanosuspension had an average particle size of 185.6 ± 7.3 nm. The pulmonary retention time was 2.8 times longer than that of the oral formulation. The expression level of the inflammatory marker TNF-α was reduced by 62.3% (P < 0.01). The therapeutic efficacy was significantly improved compared to the traditional oral formulation, demonstrating promising application potential.
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