Journal of Sustainability, Policy, and Practice
type: channel
description: A peer-reviewed, open-access academic journal dedicated to advancing interdisciplinary research and critical dialogue on the complex relationships between sustainability, policy-making, and practical implementation. The journal provides a platform for scholars, practitioners, policymakers, and educators to explore innovative approaches, theoretical frameworks, and case-based studies that address global and local challenges in sustainable development.
language: en
publication name: Journal of Sustainability, Policy, and Practice
items: Integrating AI, Data Analytics, and Policy Insights for Sustainable Urban and Economic Development
items: Semi-Supervised Feature Selection with Bias Mitigation for SME Credit Assessment Using Alternative Data
items: Reliability Assessment and Adaptive Fusion Algorithm for Multi-Sensor Data in Autonomous Driving under Adverse Weather Conditions
items: Real-Time Fraud Risk Scoring through Behavioral Sequence Analysis: An Explainable Approach for online Transaction Security
items: Effectiveness Evaluation of Adaptive Difficulty Adjustment Algorithms with Multimodal Feedback for Social Skills Training in Children with Autism Spectrum Disorder
items: Deep Learning-Based Prediction Technology for Communication Effects of Animated Character Facial Expressions
items: Performance Evaluation Methods in Contemporary Professional Practice
items: SecureCodeBERT: An Ai-Powered Model for Identifying and Categorizing High-Risk Security Vulnerabilities in Php-Based Critical Infrastructure Applications
items: RLHF-Powered Multilingual Audio Understanding: A Cross-Cultural Emotion Analysis Framework for International Communication
items: Federated Learning-Based Framework for Privacy-Protected Cross-Border Financial Risk Evaluation: Analyzing US-Asia Investment Flows
items: DeepAd-OCR: An AI-Powered Framework for Automated Recognition and Enhancement of Conversion Elements in Digital Advertisements
items: Bayesian Optimization-Based AI Framework for Nanobody Screening: Minimizing Experimental Failures in ELISA Detection Systems
items: A Reinforcement Learning Approach for Adaptive Budget Allocation in Pharmaceutical Digital Marketing: Maximizing ROI Across Patient Journey Touchpoints
items: Structural Modulation and Bioactivity Assessment of Mixed-Ligand Copper Complexes Targeting Urease
items: Two-Dimensional Copper Coordination Polymers Regulated by Tridentate Auxiliary Ligands as Efficient Urease Inhibitors
items: Post-Pandemic Digital Adaptation Across Varied Industry Sectors
items: Transition Metal Catalysts for Sustainable Chemical Transformations
items: Contemporary Challenges and Solutions Across Multiple Disciplines
items: Quality Enhancement through Systematic Analysis across Industries
items: Copper-Based Coordination Polymers for Catalysis and Inhibition
items: Dual-Metal Catalysts in Electrochemical Carbon Dioxide Conversion
items: User Engagement and Retention Strategies in Practice
items: Metal Coordination Complexes for Catalytic Application Development
items: Agricultural Sustainability through Advanced Coordination Chemistry Applications: Environmentally Friendly Enzyme Inhibitors
items: Copper Ion Coordination with Organic Linkers for Biotechnology: Materials Science and Biological Applications
items: Two-Dimensional Network Topology in Metal-Organic Framework Design: Coordination Geometry and Properties
items: Optimized Plant Nutrient Management with Copper Coordination Complex Stabilizers for Precision Agriculture
items: Coordination Chemistry Approaches to Biological Activity Modulation: Copper Complexes and Enzyme Interactions
items: Chemical Modification Strategies for Enhanced Urease Inhibition Activity: Coordination Polymer Optimization Techniques
items: Adaptive Dose Optimization Algorithm for LED-based Photodynamic Therapy Based on Deep Reinforcement Learning

Integrating AI, Data Analytics, and Policy Insights for Sustainable Urban and Economic Development
type: item
description: Sustainable urban and economic development increasingly relies on the integration of artificial intelligence (AI), data analytics, and policy insights. This paper provides a comprehensive review of the conceptual frameworks, technological applications, and governance models that enable cities to achieve efficiency, resilience, and environmental sustainability. We examine the interdependence between urban systems and economic systems, the role of multimodal data and AI-driven analytics in mobility, energy, and infrastructure management, and the transformative potential of digital twins for real-time simulation and risk reduction. Furthermore, we discuss data-driven economic strategies, industrial transformation, and policy frameworks that align technological innovation with ethical, social, and institutional considerations. The study concludes by highlighting key challenges, future research directions, and the necessity of holistic governance to ensure equitable, adaptive, and sustainable urban and economic development.
subject: Articles
  topic: section
subject: artificial intelligence
  topic: keywords
subject: data analytics
  topic: keywords
subject: sustainable urban development
  topic: keywords
subject: digital twins
  topic: keywords
subject: policy integration
  topic: keywords
subject: economic transformation
  topic: keywords
creator: Yue Xu
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-11-23
publication date: 2025-11-23
starting page: 170
ending page: 177

Semi-Supervised Feature Selection with Bias Mitigation for SME Credit Assessment Using Alternative Data
type: item
description: Credit scoring for small and medium enterprises (SMEs) faces a fundamental challenge: assessing creditworthiness when traditional financial data is unavailable. This paper presents a semi-supervised feature selection framework that addresses this challenge by leveraging alternative data sources, ranging from transaction patterns to behavioral signals. We develop a graph-based approach that reduces the requirement for labeled data by 70% while improving the area under the curve (AUC) from 0.836 to 0.871, a 4.2 percentage point increase (~5% relative) compared to the best supervised baseline. The framework integrates bias mitigation techniques, which reduce the approval-rate gap by 78.9% while maintaining stable default rates across groups, without compromising model performance. Experiments on 111,579 SME loan applications across three geographic regions demonstrate that the approach scales efficiently with O (n log n) complexity and can process 500,000 applications in approximately two hours (≈131 minutes for 500k records). The practical implications are significant: financial institutions can now assess credit risk for businesses previously considered "unscorable" due to the absence of traditional credit history. This framework facilitates broader access to capital for millions of SMEs, particularly in developing economies where formal financial records are limited.
subject: Articles
  topic: section
subject: semi-supervised learning
  topic: keywords
subject: alternative credit data
  topic: keywords
subject: algorithmic fairness
  topic: keywords
subject: SME lending
  topic: keywords
subject: feature selection
  topic: keywords
creator: Ziyi Wang
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-11-15
publication date: 2025-11-15
starting page: 156
ending page: 169

Reliability Assessment and Adaptive Fusion Algorithm for Multi-Sensor Data in Autonomous Driving under Adverse Weather Conditions
type: item
description: Atmospheric disturbances impose systematic degradation on multi-sensor perception systems in autonomous vehicles, necessitating a fundamental rethinking of sensor fusion strategies. This study presents a comprehensive reliability assessment framework combined with an adaptive fusion algorithm designed to mitigate sensor-specific performance deterioration under adverse meteorological conditions. Using an empirical dataset encompassing 10,000 hours of vehicle operation, we establish quantitative correlations between atmospheric parameters and measurement uncertainty across heterogeneous sensor modalities. Real-time trustworthiness estimation is achieved through a dynamic scoring mechanism that integrates environmental context with temporal performance evolution. The proposed adaptive fusion algorithm performs reliability-weighted integration through probabilistic decision modeling, optimizing sensor data combination while minimizing perception errors. Experimental validation demonstrates that the method improves object detection accuracy by 22.9 percentage points compared with majority-vote fusion (AP@0.5) and by 18.4 percentage points compared with fixed-weight fusion in heavy rain (AP@0.5). Furthermore, the false positive rate is reduced by 66-73% relative to the fixed-weight and majority-vote baselines, respectively. These improvements directly enhance collision avoidance performance, substantially advancing the safety and robustness of autonomous vehicles operating in challenging environmental conditions.
subject: Articles
  topic: section
subject: multi-sensor fusion
  topic: keywords
subject: reliability assessment
  topic: keywords
subject: adverse weather
  topic: keywords
subject: autonomous driving
  topic: keywords
creator: Yi Guo
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-11-15
publication date: 2025-11-15
starting page: 143
ending page: 155

Real-Time Fraud Risk Scoring through Behavioral Sequence Analysis: An Explainable Approach for online Transaction Security
type: item
description: Payment fraud continues to evolve, resulting in global losses of approximately $33.83 billion last year alone. We developed a system capable of highly effective fraud detection by analyzing spending behavior over time rather than focusing solely on individual transactions. While fraudsters can imitate a single purchase, it is far more difficult for them to replicate an entire behavioral history. Our key innovation lies in a hierarchical architecture that combines modified gated recurrent units (GRUs) with gradient boosting methods, allowing each component to perform its specialized role. The proposed system achieves an area under the precision-recall curve (AUPRC) of 0.876 and a Recall@1%FPR of 0.834 on the IEEE-CIS dataset comprising 590,540 transactions. In production-level stress tests, it sustains throughput up to 12,000 transactions per second under peak load conditions (with an average daily volume of approximately 3.4 million across partner institutions) and maintains a median latency of 47.3 ms (95% CI: [45.8, 48.9] ms; p95: 67.2 ms), remaining consistently below the 50 ms operational threshold. The system's core mechanism involves a temporal-gap-aware gating module within the modified GRU encoder that captures irregular intervals between purchases, effectively distinguishing genuine consumer behavior from fraudulent activity. This encoder is integrated with an ensemble of LightGBM, XGBoost, and Random Forest models, enabling robust voting-based decision fusion. To balance interpretability and performance, the system employs selective explainability-providing gradient-based attributions and counterfactual explanations only for the 5% of transactions flagged as high-risk-thereby ensuring regulatory transparency without compromising speed. Extensive validation using real banking datasets from three financial institutions confirmed its reliability and practicality. While not flawless, the system demonstrates sufficient robustness and interpretability for large-…
subject: Articles
  topic: section
subject: behavioral sequence analysis
  topic: keywords
subject: fraud detection
  topic: keywords
subject: explainable AI
  topic: keywords
subject: real-time processing
  topic: keywords
creator: Minghua Deng
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-11-15
publication date: 2025-11-15
starting page: 130
ending page: 142

Effectiveness Evaluation of Adaptive Difficulty Adjustment Algorithms with Multimodal Feedback for Social Skills Training in Children with Autism Spectrum Disorder
type: item
description: Children diagnosed with autism spectrum disorder display substantial heterogeneity in social communication skills, necessitating intervention strategies that dynamically adapt to individual developmental trajectories. We propose a hierarchical reinforcement learning framework that integrates multimodal behavioral streams to guide difficulty progression in therapeutic social scenarios. Skill development is modeled as a constrained Markov decision process, with difficulty vectors d in D evolving according to composite performance signals p(t) and engagement indicators e(t), where the optimization objective J = E [sum over t of gamma ^ t * (r_skill (s_t, a_t) + lambda * r_engage (s_t, a_t))] balances immediate skill gains against sustained participation. Three synchronized channels-facial landmarks tracked via 68-point models sampled at 120 Hz, acoustic features represented by 13-dimensional MFCCs, and skeletal configurations captured across 25 anatomical joints-are processed through temporal convolutional networks. Attention-weighted aggregation f_fusion = sum over i of alpha_i * phi_i (x_i) allows each modality-specific encoder phi_i to contribute proportionally to its instantaneous reliability. Clinical trials involving 124 participants (ages 6-14, ADOS-2 scores 12.4 ± 3.2) demonstrate a 42.3% acceleration in competency acquisition compared with therapist-directed baselines (hierarchical model coefficient beta_time×condition = 1.42, SE = 0.18, t (1984) = 7.89, p < 0.001). Transition prediction between difficulty states achieves 87.4% accuracy. Power-law retention analysis indicates reduced forgetting in the adaptive framework (b_adaptive = 0.084 versus b_control = 0.162), with 78.4% of acquired competencies maintained at a 12-week follow-up.
subject: Articles
  topic: section
subject: autism interventions
  topic: keywords
subject: reinforcement learning architectures
  topic: keywords
subject: behavioral signal processing
  topic: keywords
subject: adaptive training system
  topic: keywords
subject: multimodal fusion
  topic: keywords
creator: Yaqing Bai
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-11-15
publication date: 2025-11-15
starting page: 117
ending page: 129

Deep Learning-Based Prediction Technology for Communication Effects of Animated Character Facial Expressions
type: item
description: The increasing demand for engaging animated content requires advanced mechanisms to predict communication effectiveness prior to production completion. This study introduces a deep learning framework designed to forecast audience engagement through automated analysis of animated characters' facial expressions. The methodology combines convolutional neural networks for precise facial feature extraction with transformer architectures for temporal prediction of communication impact. By processing visual expression data and correlating it with audience response patterns, the framework achieves 87.3% accuracy in predicting viral potential across a range of animation styles. Compared to traditional content evaluation methods, this approach significantly reduces production iteration cycles by 42% while preserving creative authenticity. Experimental validation using 15,000 animated sequences from commercial productions confirms the framework's effectiveness in predicting audience emotional resonance and content shareability across diverse demographic groups.
subject: Articles
  topic: section
subject: facial expression recognition
  topic: keywords
subject: deep learning
  topic: keywords
subject: animation content analysis
  topic: keywords
subject: audience engagement prediction
  topic: keywords
creator: Zi Wang
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-11-15
publication date: 2025-11-15
starting page: 105
ending page: 116

Performance Evaluation Methods in Contemporary Professional Practice
type: item
description: Performance evaluation methods have become fundamental mechanisms for organizational success in contemporary professional practice, enabling businesses to assess operational efficiency, strategic alignment, and competitive positioning in rapidly evolving markets. This paper examines the multifaceted landscape of performance measurement and management systems, exploring their implementation processes, design frameworks, and practical applications across diverse professional contexts. The study investigates how organizations adapt traditional performance evaluation approaches to address challenges posed by digital transformation, post-pandemic operational shifts, and the increasing complexity of business environments. Through systematic analysis of established frameworks and emerging methodologies, this research demonstrates how performance measurement systems serve as critical tools for change initiatives, continuous improvement programs, and strategic decision-making processes. The paper further explores the role of organizational culture in shaping measurement practices and examines obstacles that hinder effectiveness in implementation. By synthesizing contemporary research and practical applications, this work provides comprehensive insights into how performance evaluation methods support professional practice across sectors including small and medium enterprises, industrial collaborations, and project-based organizations, while highlighting the theoretical foundations that underpin successful measurement and management control systems.
subject: Articles
  topic: section
subject: performance measurement
  topic: keywords
subject: management systems
  topic: keywords
subject: implementation process
  topic: keywords
subject: organizational practice
  topic: keywords
subject: continuous improvement
  topic: keywords
subject: digital transformation
  topic: keywords
creator: Li Peng
creator: Xia Wu
creator: Yu Fang
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-11-11
publication date: 2025-11-11
starting page: 95
ending page: 104

SecureCodeBERT: An Ai-Powered Model for Identifying and Categorizing High-Risk Security Vulnerabilities in Php-Based Critical Infrastructure Applications
type: item
description: Critical infrastructure systems extensively utilize PHP applications which face significant security challenges that traditional detection methods inadequately address. This paper presents SecureCodeBERT, a specialized transformer-based model for detecting and classifying high-risk security vulnerabilities in PHP applications deployed within critical infrastructure environments. The architecture incorporates PHP-specific adaptations through specialized tokenization strategies and contextual code understanding mechanisms. A comprehensive multi-stage detection framework combines syntactic parsing, semantic analysis, and contextual vulnerability pattern recognition to identify complex exploitation vectors. The multi-level classification system categorizes vulnerabilities based on both technical severity and operational impact, enabling prioritized remediation. Experimental evaluation on a dataset comprising 140 applications across five critical infrastructure sectors demonstrates SecureCodeBERT's superior performance with precision rates of 0.892 and recall rates of 0.867, representing significant improvements over traditional static analysis tools (+21.0%) and generic code analysis models (+7.6%). Sector-specific vulnerability pattern analysis reveals distinct security challenges across energy management, healthcare, financial services, transportation, and water management applications. Case studies validate the model's effectiveness in production environments, demonstrating particular strengths in detecting sophisticated authentication bypass, SQL injection, and command injection vulnerabilities that conventional tools frequently miss.
subject: Articles
  topic: section
subject: vulnerability detection
  topic: keywords
subject: PHP security
  topic: keywords
subject: critical infrastructure protection
  topic: keywords
subject: transformer-based models
  topic: keywords
creator: Jin Zhang
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-11-06
publication date: 2025-11-06
starting page: 80
ending page: 94

RLHF-Powered Multilingual Audio Understanding: A Cross-Cultural Emotion Analysis Framework for International Communication
type: item
description: The proliferation of multilingual audio content across global communication platforms presents significant challenges in understanding cross-cultural sentiment expressions. This paper introduces a novel framework that integrates Reinforcement Learning from Human Feedback (RLHF) with advanced multilingual audio processing techniques to enhance cross-cultural sentiment analysis capabilities. Our approach addresses the complexities of language-specific emotional expressions and cultural nuances through an adaptive learning mechanism that continuously refines understanding based on human feedback. The proposed framework demonstrates superior performance in identifying sentiment patterns across diverse linguistic and cultural contexts, achieving accuracy improvements of 18.3% over traditional approaches. The system incorporates multi-dimensional feedback fusion mechanisms and dynamic reward estimation to optimize sentiment classification across 12 major languages. Experimental results reveal enhanced cross-cultural communication effectiveness through improved sentiment detection accuracy and cultural context preservation. The framework's applications extend to global diplomatic communications, international business negotiations, and cross-border social media monitoring, contributing to more effective intercultural understanding and communication facilitation in increasingly connected world environments.
subject: Articles
  topic: section
subject: RLHF
  topic: keywords
subject: multilingual audio processing
  topic: keywords
subject: cross-cultural sentiment analysis
  topic: keywords
subject: global communication
  topic: keywords
creator: Ye Lei
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-11-06
publication date: 2025-11-06
starting page: 66
ending page: 79

Federated Learning-Based Framework for Privacy-Protected Cross-Border Financial Risk Evaluation: Analyzing US-Asia Investment Flows
type: item
description: This paper presents a novel federated learning framework for privacy-preserving cross-border financial risk assessment, specifically focused on US-Asia investment flows. Cross-border financial transactions face significant challenges in risk assessment due to disparate regulatory environments, data sovereignty requirements, and privacy constraints across jurisdictions. Our proposed architecture addresses these challenges through a multi-layered approach that incorporates differential privacy, homomorphic encryption, and secure aggregation techniques while enabling collaborative model training without raw data exchange. Experimental results demonstrate that the proposed framework achieves 94.5% detection accuracy with 217ms latency in real-world case studies, outperforming conventional federated learning approaches by 4.3-7.2% across key performance metrics while maintaining regulatory compliance. The architecture reduces false positives by 73% compared to baseline methods while preserving data locality requirements. Privacy protection analysis confirms resilience against multiple attack vectors with only 0.4% model inversion success rate compared to 7.2% for state-of-the-art alternatives. This research establishes a foundation for enhanced cross-jurisdictional financial risk assessment that balances analytical capabilities with strict privacy preservation, enabling financial institutions to develop more sophisticated risk models across US and Asian markets without compromising regulatory compliance or data sovereignty.
subject: Articles
  topic: section
subject: federated learning
  topic: keywords
subject: financial risk assessment
  topic: keywords
subject: cross-border privacy
  topic: keywords
subject: investment flow analysis
  topic: keywords
creator: Yiyi Cai
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-11-06
publication date: 2025-11-06
starting page: 50
ending page: 65

DeepAd-OCR: An AI-Powered Framework for Automated Recognition and Enhancement of Conversion Elements in Digital Advertisements
type: item
description: Digital advertisements represent a critical business asset requiring continuous optimization to maximize conversion rates. While traditional approaches rely on manual analysis and heuristic adjustments, this paper introduces DeepAd-OCR, an AI-driven framework for real-time recognition and optimization of conversion elements in digital advertisements. The framework integrates enhanced optical character recognition with deep learning techniques to automatically identify, analyze, and optimize critical conversion elements including call-to-action buttons, pricing information, and value propositions. Experimental evaluation conducted on a dataset of 15,000 advertisements across multiple platforms demonstrates that DeepAd-OCR achieves 96.8% text recognition accuracy and 94.3% visual element detection accuracy, significantly outperforming traditional methods. Implementation across various industry sectors resulted in average conversion rate improvements of 22.8%, with e-commerce platforms experiencing the highest gains at 27.4%. The system's real-time optimization capabilities prove particularly valuable during time-sensitive promotions, dynamically adjusting emphasis elements based on performance metrics. Case studies validate the framework's effectiveness in practical applications, while acknowledging limitations in handling animated content and computational requirements. The DeepAd-OCR framework advances the state-of-the-art in advertisement optimization by combining sophisticated element recognition with adaptive optimization algorithms, enabling advertisers to maximize conversion potential through automated, data-driven adjustments.
subject: Articles
  topic: section
subject: optical character recognition
  topic: keywords
subject: conversion rate optimization
  topic: keywords
subject: digital advertising
  topic: keywords
subject: artificial intelligence
  topic: keywords
creator: Xin Lu
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-11-06
publication date: 2025-11-06
starting page: 32
ending page: 49

Bayesian Optimization-Based AI Framework for Nanobody Screening: Minimizing Experimental Failures in ELISA Detection Systems
type: item
description: This paper presents a novel AI-driven Bayesian optimization framework for nanobody screening that significantly reduces experimental failures in ELISA-based detection systems. Nanobody screening protocols traditionally suffer from high failure rates, resource inefficiency, and poor reproducibility due to complex parameter interdependencies. The proposed framework integrates Gaussian process surrogate models with dynamically adjusted acquisition functions to navigate high-dimensional parameter spaces efficiently. A comprehensive parameter space definition encompasses eight critical ELISA variables, including incubation conditions, reagent concentrations, and protocol timing. The framework employs a Matérn 5/2 kernel function with empirically determined hyperparameters to model the relationship between experimental parameters and detection performance. Validation across multiple target proteins demonstrates a 3.42× improvement in experimental efficiency compared to traditional grid search methods, with success rates increasing from a baseline of 27.3% to 78.3% for SARS-CoV-2 RBD detection. Statistical validation confirms these improvements with high effect sizes (d = 1.82) and statistical power (0.997). The framework achieved a 67.8% reduction in experimental costs while improving reproducibility scores from 0.85 to 0.91. Cross-laboratory validation confirms protocol transferability, addressing a critical challenge in biomedical research standardization. This approach establishes a foundation for more efficient and reliable nanobody development pipelines with broad implications for biomedical research optimization.
subject: Articles
  topic: section
subject: bayesian optimization
  topic: keywords
subject: nanobody screening
  topic: keywords
subject: ELISA optimization
  topic: keywords
subject: experimental design automation
  topic: keywords
creator: Haofeng Ye
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-11-06
publication date: 2025-11-06
starting page: 16
ending page: 31

A Reinforcement Learning Approach for Adaptive Budget Allocation in Pharmaceutical Digital Marketing: Maximizing ROI Across Patient Journey Touchpoints
type: item
description: This paper introduces a novel reinforcement learning framework for dynamic budget allocation in pharmaceutical digital advertising, addressing critical challenges in optimizing marketing resources across patient journey touchpoints. Traditional budget allocation methods in pharmaceutical marketing fail to adapt to complex, multi-channel environments and regulatory constraints, resulting in suboptimal ROI. We propose a comprehensive reinforcement learning approach that models budget allocation as a sequential decision-making problem, with a state space encompassing channel performance metrics, audience characteristics, and regulatory parameters. The framework incorporates a multi-objective reward function balancing immediate conversion metrics with long-term value generation while maintaining compliance requirements. Experimental validation using 24 months of real-world pharmaceutical marketing data across five therapeutic areas demonstrates significant performance improvements over conventional methodologies. The reinforcement learning framework achieved an average ROI increase of 42.3% compared to baseline methods, with particularly strong performance in rare disease categories (69.9% improvement). The system demonstrates effective learning convergence across diverse therapeutic contexts while maintaining regulatory compliance. This research provides both theoretical contributions to AI applications in healthcare marketing and practical implementation strategies for pharmaceutical companies seeking to optimize digital advertising investments across increasingly complex patient journey touchpoints.
subject: Articles
  topic: section
subject: reinforcement learning
  topic: keywords
subject: pharmaceutical marketing
  topic: keywords
subject: dynamic budget allocation
  topic: keywords
subject: patient journey optimization
  topic: keywords
creator: Zhenghao Pan
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-11-06
publication date: 2025-11-06
starting page: 1
ending page: 15

Structural Modulation and Bioactivity Assessment of Mixed-Ligand Copper Complexes Targeting Urease
type: item
description: Mixed-ligand copper complexes have emerged as promising candidates for enzyme inhibition due to their versatile coordination chemistry and tunable biological activity. In this study, a series of mixed-ligand copper complexes were designed and synthesized with structural modifications aimed at enhancing urease inhibitory activity. The complexes were comprehensively characterized using NMR, IR, UV-Vis spectroscopy, mass spectrometry, and X-ray crystallography where feasible, confirming successful coordination and revealing variations in coordination geometry. Urease inhibition assays demonstrated that ligand structure significantly influenced biological activity, with electron-donating and sterically accessible ligands exhibiting higher potency. Kinetic studies indicated competitive or mixed-type inhibition, while molecular docking simulations supported these findings by showing favorable interactions with key residues in the urease active site. Structure-activity relationship analysis highlighted the critical roles of electronic properties, steric effects, and coordination geometry in modulating enzyme inhibition. The results provide valuable insights into rational ligand design for copper-based metalloenzyme inhibitors and establish mixed-ligand copper complexes as potential candidates for therapeutic applications targeting urease-related pathologies.
subject: Articles
  topic: section
subject: copper complexes
  topic: keywords
subject: mixed ligands
  topic: keywords
subject: urease inhibition
  topic: keywords
subject: Structure-Activity Relationship (SAR)
  topic: keywords
subject: enzyme kinetics
  topic: keywords
subject: molecular docking
  topic: keywords
creator: Adrian Lee
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-10-28
publication date: 2025-10-28
starting page: 308
ending page: 314

Two-Dimensional Copper Coordination Polymers Regulated by Tridentate Auxiliary Ligands as Efficient Urease Inhibitors
type: item
description: Two-dimensional (2D) copper coordination polymers, characterized by their unique layered structures, multiple coordination sites, and tunable pore channels, have attracted considerable attention due to their potential applications in urease inhibition and agricultural environmental management. The combination of structural flexibility, high surface area, and adjustable metal-ligand coordination environments allows these polymers to interact effectively with enzymatic active sites, offering a promising platform for the development of highly efficient and controllable enzyme inhibitors. In this study, tridentate auxiliary ligands were employed as structural regulators to design and construct novel 2D copper coordination polymers. The influence of these ligands on the polymeric architecture and urease inhibitory performance was systematically investigated. Single-crystal X-ray diffraction analysis revealed that the tridentate ligands not only effectively modulate the coordination environment of copper centers but also direct the topology of the 2D layered networks, promoting the exposure of active sites that are critical for enzyme binding. The resulting polymers exhibit a well-defined layered structure with interconnected channels, which can facilitate substrate accessibility and enhance inhibitory efficiency. Thermogravimetric analysis (TGA) and powder X-ray diffraction (PXRD) measurements confirmed that the synthesized polymers possess excellent thermal stability and retain their crystallinity under experimental conditions, indicating robust structural integrity suitable for practical applications. In vitro urease inhibition assays demonstrated that the novel polymers exhibit high inhibitory activity, with IC₅₀ values significantly lower than those of analogous systems constructed using bidentate auxiliary ligands. These results suggest that the incorporation of tridentate ligands markedly enhances enzyme inhibition, likely due to the combined effects of increased a…
subject: Articles
  topic: section
subject: two-dimensional copper coordination polymers
  topic: keywords
subject: tridentate auxiliary ligands
  topic: keywords
subject: urease inhibition
  topic: keywords
subject: crystal structure
  topic: keywords
subject: thermal stability
  topic: keywords
subject: agricultural application
  topic: keywords
creator: Sophia Bennett
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-10-27
publication date: 2025-10-27
starting page: 301
ending page: 307

Post-Pandemic Digital Adaptation Across Varied Industry Sectors
type: item
description: The COVID-19 pandemic catalyzed unprecedented digital transformation across diverse industry sectors, fundamentally altering operational paradigms and accelerating technology adoption timelines by years. This paper examines post-pandemic digital adaptation patterns across multiple domains including architectural design, business model innovation, software development, manufacturing, construction management, and professional training. The investigation reveals that digital adaptation extended beyond emergency responses to encompass strategic repositioning, operational restructuring, and fundamental reconsideration of value delivery mechanisms. Through systematic analysis of transformation patterns across sectors, this study identifies convergent themes including remote work integration, digital platform adoption, automation acceleration, and data-driven decision-making enhancement. The findings demonstrate that successful digital adaptation required balancing technological implementation with organizational culture transformation, workforce capability development, and stakeholder engagement. Organizations demonstrating resilience during pandemic disruptions exhibited characteristics including leadership commitment to digital initiatives, investment in technological infrastructure, and cultivation of adaptive organizational cultures. These insights contribute to understanding how crisis-driven digital acceleration creates lasting changes in professional practice, competitive dynamics, and operational methodologies across varied industry contexts, providing guidance for organizations navigating ongoing digital transformation challenges.
subject: Articles
  topic: section
subject: digital transformation
  topic: keywords
subject: post-pandemic adaptation
  topic: keywords
subject: business model innovation
  topic: keywords
subject: remote work
  topic: keywords
subject: organizational resilience
  topic: keywords
subject: technological acceleration
  topic: keywords
creator: Amanda Lee
creator: Rajesh Kumar
creator: Yuki Matsumoto
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-10-26
publication date: 2025-10-26
starting page: 291
ending page: 300

Transition Metal Catalysts for Sustainable Chemical Transformations
type: item
description: The development of sustainable chemical transformations has become increasingly critical in addressing global environmental and resource challenges. Transition metal catalysts, particularly those based on earth-abundant metals, have emerged as pivotal enablers of green chemistry and sustainable industrial processes. This comprehensive review examines the role of transition metal catalysts in facilitating sustainable chemical transformations, with emphasis on biomass conversion, carbon dioxide reduction, and coordination polymer applications. The review explores various catalyst systems including transition metal carbides, dichalcogenides, and copper-based coordination polymers, highlighting their mechanisms, advantages, and applications in renewable fuel production and value-added chemical synthesis. Special attention is given to the design principles that enhance catalytic efficiency and selectivity while maintaining environmental compatibility. The integration of earth-abundant metals such as iron, copper, cobalt, and nickel offers economically viable alternatives to precious metal catalysts, thereby advancing the commercial feasibility of sustainable chemical processes. This review provides insights into current challenges and future directions for developing next-generation transition metal catalysts that can meet the demands of sustainable chemistry.
subject: Articles
  topic: section
subject: transition metal catalysts
  topic: keywords
subject: sustainable chemistry
  topic: keywords
subject: biomass conversion
  topic: keywords
subject: earth-abundant metals
  topic: keywords
subject: coordination polymers
  topic: keywords
subject: carbon dioxide reduction
  topic: keywords
creator: Rodriguez Chen
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-10-26
publication date: 2025-10-26
starting page: 282
ending page: 290

Contemporary Challenges and Solutions Across Multiple Disciplines
type: item
description: Contemporary professional environments face unprecedented challenges requiring integrated approaches that transcend traditional disciplinary boundaries. This paper examines critical issues across diverse sectors including digital technology implementation, performance optimization strategies, risk management frameworks, and adaptive professional practices. The investigation reveals that modern challenges share common characteristics including rapid technological evolution, data-driven decision requirements, and the necessity for continuous adaptation to changing operational contexts. Through systematic analysis of current practices in professional development, digital transformation initiatives, strategic planning methodologies, and performance evaluation systems, this study identifies convergent solutions applicable across multiple domains. The findings demonstrate that successful navigation of contemporary challenges requires holistic frameworks that integrate technological innovation with human-centered design principles. The paper presents comparative analyses of implementation strategies, efficiency metrics, and optimization approaches that provide actionable insights for practitioners across various professional fields. These insights contribute to understanding how interdisciplinary collaboration and knowledge integration can address complex problems facing modern organizations and professional communities.
subject: Articles
  topic: section
subject: interdisciplinary collaboration
  topic: keywords
subject: digital transformation
  topic: keywords
subject: performance optimization
  topic: keywords
subject: risk management
  topic: keywords
subject: professional practice evolution
  topic: keywords
subject: integrated solutions
  topic: keywords
creator: Nina Patel
creator: Takeshi Sato
creator: Carlos Mendez
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-10-25
publication date: 2025-10-25
starting page: 273
ending page: 281

Quality Enhancement through Systematic Analysis across Industries
type: item
description: Quality enhancement has emerged as a fundamental imperative for organizations operating across diverse industrial contexts where competitive pressures and stakeholder expectations continuously escalate. This paper examines systematic approaches to quality improvement through cross-sectoral analysis encompassing professional practice development, technological innovation, digital transformation, and operational excellence frameworks. By investigating quality management principles within contexts ranging from traditional pedagogical methods to contemporary digital manufacturing systems, this research identifies universal mechanisms that transcend industry boundaries. The study explores theoretical foundations of quality management including critical success factors, implementation practices, and performance relationships while examining how organizations leverage systematic analysis to achieve sustainable quality improvements. Through comprehensive examination of measurement frameworks, continuous improvement methodologies, and adaptive quality strategies, this paper demonstrates that successful quality enhancement requires integrated approaches combining rigorous assessment, evidence-based decision making, and sustained organizational commitment. The findings reveal that organizations achieving superior quality outcomes implement systematic analysis processes that identify improvement opportunities, validate intervention effectiveness, and foster cultures of continuous excellence. This interdisciplinary investigation provides practitioners with actionable frameworks for quality enhancement applicable across varied industrial environments while advancing theoretical understanding of quality management effectiveness.
subject: Articles
  topic: section
subject: quality management
  topic: keywords
subject: systematic analysis
  topic: keywords
subject: continuous improvement
  topic: keywords
subject: performance optimization
  topic: keywords
subject: digital transformation
  topic: keywords
subject: operational excellence
  topic: keywords
creator: Jing Li
creator: Min Zhou
creator: Feng Zhao
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-10-25
publication date: 2025-10-25
starting page: 259
ending page: 272

Copper-Based Coordination Polymers for Catalysis and Inhibition
type: item
description: Copper-based coordination polymers have emerged as versatile materials exhibiting remarkable performance in catalytic transformations and biological inhibition applications. These crystalline materials feature copper ions coordinated with organic ligands to form extended network structures that combine the advantages of homogeneous and heterogeneous catalysis. The structural diversity, tunable porosity, and accessible metal centers make copper coordination polymers attractive candidates for various catalytic reactions including carbon dioxide conversion, organic transformations, and photocatalytic processes. Additionally, these materials demonstrate significant potential as enzyme inhibitors, particularly for urease inhibition relevant to agricultural and medical applications. This paper comprehensively examines the synthesis, structural characteristics, catalytic properties, and inhibition activities of copper-based coordination polymers. The discussion encompasses design principles, structure-activity relationships, and mechanistic insights into their catalytic and biological functions. Special emphasis is placed on how structural modifications through ligand selection and secondary building units influence catalytic efficiency and selectivity. The findings highlight the multifunctional nature of copper coordination polymers and their promising prospects for advancing sustainable chemistry and therapeutic applications.
subject: Articles
  topic: section
subject: copper coordination polymers
  topic: keywords
subject: catalysis
  topic: keywords
subject: enzyme inhibition
  topic: keywords
subject: metal-organic frameworks
  topic: keywords
subject: structural design
  topic: keywords
subject: carbon dioxide conversion
  topic: keywords
creator: Li Wang
creator: Mark Johnson
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-10-25
publication date: 2025-10-25
starting page: 247
ending page: 258

Dual-Metal Catalysts in Electrochemical Carbon Dioxide Conversion
type: item
description: The escalating atmospheric carbon dioxide concentration has intensified the urgency for developing efficient carbon dioxide conversion technologies. Electrochemical carbon dioxide reduction represents a promising approach to convert carbon dioxide into valuable chemicals and fuels while utilizing renewable electricity. Dual-metal catalysts have emerged as a breakthrough strategy, offering synergistic effects that surpass the limitations of single-metal catalysts. These bimetallic systems demonstrate enhanced catalytic activity, improved product selectivity, and superior stability through electronic modification, geometric arrangement, and cooperative catalytic mechanisms. This paper comprehensively examines recent developments in dual-metal catalysts for electrochemical carbon dioxide conversion, focusing on copper-based bimetallic combinations including copper-palladium, copper-bismuth, and copper-zinc systems. The discussion encompasses mechanistic insights, synthetic strategies, structure-activity relationships, and performance optimization approaches. By analyzing various bimetallic configurations and their catalytic behaviors, this work highlights critical factors governing product distribution and conversion efficiency. The findings underscore the potential of dual-metal catalysts in advancing sustainable carbon dioxide utilization technologies toward industrial implementation.
subject: Articles
  topic: section
subject: dual-metal catalysts
  topic: keywords
subject: carbon dioxide reduction
  topic: keywords
subject: electrochemical conversion
  topic: keywords
subject: bimetallic systems
  topic: keywords
subject: copper catalysts
  topic: keywords
subject: synergistic effects
  topic: keywords
creator: Jun Wang
creator: Lisa Chen
creator: Thomas Lee
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-10-25
publication date: 2025-10-25
starting page: 237
ending page: 246

User Engagement and Retention Strategies in Practice
type: item
description: User engagement and retention have become critical determinants of organizational success across diverse professional domains. This paper examines contemporary strategies for fostering sustained user interaction and commitment through an interdisciplinary lens that encompasses digital platforms, professional practice evolution, and technological innovation. By analyzing engagement frameworks within contexts ranging from online brand communities to efficiency-driven operational systems, this research identifies core principles that transcend sector boundaries. The study explores multidimensional engagement constructs, including cognitive, emotional, and behavioral components, while examining how modern organizations leverage continuous innovation and adaptive methodologies to maintain user investment. Through systematic analysis of engagement metrics, measurement frameworks, and retention mechanisms, this paper demonstrates that successful engagement strategies share common characteristics of value creation, personalized interaction, and sustained quality delivery. The findings reveal that organizations achieving high retention rates implement integrated approaches combining technological advancement, responsive adaptation to changing contexts, and meaningful stakeholder relationships. This comprehensive examination provides actionable insights for practitioners seeking to optimize user engagement across various professional environments.
subject: Articles
  topic: section
subject: user engagement
  topic: keywords
subject: retention strategies
  topic: keywords
subject: brand community
  topic: keywords
subject: digital transformation
  topic: keywords
subject: performance optimization
  topic: keywords
subject: stakeholder relationships
  topic: keywords
creator: Hui Chen
creator: Ming Wang
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-10-24
publication date: 2025-10-24
starting page: 225
ending page: 236

Metal Coordination Complexes for Catalytic Application Development
type: item
description: Metal coordination complexes have emerged as pivotal materials in advancing catalytic technologies across diverse chemical transformations. The strategic design of coordination environments, particularly through dual-metal configurations and auxiliary ligand modulation, has revolutionized catalytic efficiency and selectivity in numerous applications. This comprehensive review examines the fundamental principles governing metal coordination chemistry and their translation into practical catalytic systems. Special emphasis is placed on copper-based coordination polymers, dual-metal site architectures, and metal-organic frameworks that demonstrate exceptional performance in electrocatalytic carbon dioxide reduction, enzymatic inhibition, and sustainable chemical synthesis. The synergistic interplay between metal centers and organic linkers creates unique microenvironments that facilitate substrate activation and product formation through precisely controlled reaction pathways. Recent developments in node modification, auxiliary ligand engineering, and spatial confinement effects have significantly enhanced catalytic turnover frequencies and product selectivities. This paper systematically analyzes structural design principles, mechanistic insights, and performance metrics of metal coordination complexes while highlighting emerging trends in green catalysis, energy conversion applications, and biologically relevant transformations. The discussion encompasses both homogeneous and heterogeneous catalytic systems, demonstrating how coordination chemistry principles enable sustainable solutions to contemporary chemical challenges.
subject: Articles
  topic: section
subject: metal coordination complexes
  topic: keywords
subject: catalytic applications
  topic: keywords
subject: dual-metal sites
  topic: keywords
subject: copper polymers
  topic: keywords
subject: electrocatalysis
  topic: keywords
subject: auxiliary ligands
  topic: keywords
creator: Ming Chen
creator: Sarah Thompson
creator: Wei Zhang
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-10-24
publication date: 2025-10-24
starting page: 216
ending page: 224

Agricultural Sustainability through Advanced Coordination Chemistry Applications: Environmentally Friendly Enzyme Inhibitors
type: item
description: The integration of coordination chemistry principles with agricultural sustainability represents a transformative approach to modern farming practices. This paper examines the development and application of environmentally friendly enzyme inhibitors derived from coordination compounds, specifically focusing on their role in sustainable agricultural systems. The research explores how coordination-driven innovations in catalytic processes can advance sustainability in chemical production while simultaneously addressing agricultural challenges. The investigation reveals that copper-based coordination polymers demonstrate exceptional efficacy as urease inhibitors, offering significant potential for reducing nitrogen losses in agricultural soils. Furthermore, the study examines the broader implications of coordination mechanisms in agri-food chain sustainability assessment, highlighting the critical role of ligninolytic enzymes in sustainable agriculture. The findings demonstrate that novel two-dimensional coordination polymers, regulated by auxiliary ligands, can achieve high-efficiency enzyme inhibition while maintaining environmental compatibility. The research also addresses the integration of metal complexes with biodegradable complexing agents in soil amendment applications, presenting promising opportunities for enhanced soil water availability in drought-prone regions. This comprehensive analysis establishes the foundation for implementing coordination chemistry-based solutions in sustainable agricultural practices, emphasizing the potential for reducing chemical inputs while maintaining productivity and environmental stewardship.
subject: Articles
  topic: section
subject: coordination chemistry
  topic: keywords
subject: enzyme inhibitors
  topic: keywords
subject: agricultural sustainability
  topic: keywords
subject: copper-based polymers
  topic: keywords
subject: urease inhibition
  topic: keywords
subject: environmental compatibility
  topic: keywords
creator: James Rodriguez
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-10-20
publication date: 2025-10-20
starting page: 206
ending page: 215

Copper Ion Coordination with Organic Linkers for Biotechnology: Materials Science and Biological Applications
type: item
description: Copper-based coordination polymers and metal-organic frameworks represent a rapidly expanding frontier in biotechnology applications, offering unique advantages through their tunable structural properties and inherent bioactivity. This comprehensive review examines the current state of copper ion coordination with organic linkers, focusing on their materials science foundations and diverse biological applications. The investigation encompasses the fundamental coordination chemistry of copper centers, structural design principles for biomedical applications, and emerging therapeutic strategies including anticancer treatments and wound healing applications. Recent advances in copper-mediated cuproptosis mechanisms have opened new avenues for targeted cancer therapy, while the antimicrobial properties of copper-based frameworks show promise for infection control and tissue regeneration. The structural versatility of these materials, achieved through systematic ligand modification and secondary building unit engineering, enables precise control over biological activity and biocompatibility. Current challenges include optimizing stability in biological media, controlling copper ion release kinetics, and minimizing cytotoxicity while maintaining therapeutic efficacy. This review synthesizes recent developments in copper coordination chemistry for biotechnology, highlighting breakthrough applications in drug delivery, biosensing, and regenerative medicine. The analysis reveals significant potential for copper-based coordination materials in next-generation biomedical technologies, with particular emphasis on their role in personalized medicine and targeted therapeutic interventions.
subject: Articles
  topic: section
subject: copper coordination
  topic: keywords
subject: metal-organic frameworks
  topic: keywords
subject: biotechnology applications
  topic: keywords
subject: cuproptosis
  topic: keywords
subject: biomedical materials
  topic: keywords
subject: coordination polymers
  topic: keywords
creator: Farah Khan
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-10-18
publication date: 2025-10-18
starting page: 196
ending page: 205

Two-Dimensional Network Topology in Metal-Organic Framework Design: Coordination Geometry and Properties
type: item
description: Two-dimensional metal-organic frameworks (2D MOFs) have emerged as a fascinating class of crystalline materials that exhibit unique structural properties arising from their distinct network topologies and coordination geometries. This comprehensive review examines the intricate relationship between network topology and material properties in 2D MOF systems, focusing on how coordination geometry influences the overall framework architecture and subsequent functional characteristics. The synthesis strategies for achieving specific topological arrangements are discussed, highlighting the role of ligand design and metal node selection in controlling network dimensionality. The study explores various coordination environments and their impact on electronic, optical, and mechanical properties of 2D MOFs. Furthermore, the applications of these materials in diverse fields including biosensing, energy conversion, and environmental remediation are analyzed through the lens of their topological features. The correlation between structural parameters and performance metrics reveals fundamental design principles for engineering 2D MOFs with tailored properties. Recent advances in computational modeling and experimental characterization techniques have provided deeper insights into structure-property relationships in these materials. This work provides a systematic framework for understanding how topological considerations can guide the rational design of next-generation 2D MOF materials with enhanced functionalities for specific applications.
subject: Articles
  topic: section
subject: metal-organic frameworks
  topic: keywords
subject: two-dimensional materials
  topic: keywords
subject: network topology
  topic: keywords
subject: coordination geometry
  topic: keywords
subject: structure-property relationships
  topic: keywords
subject: framework design
  topic: keywords
creator: Yue Qian
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-10-17
publication date: 2025-10-17
starting page: 186
ending page: 195

Optimized Plant Nutrient Management with Copper Coordination Complex Stabilizers for Precision Agriculture
type: item
description: Modern precision agriculture demands innovative approaches to nutrient management that optimize crop productivity while minimizing environmental impact. This paper examines the application of copper coordination complex stabilizers in plant nutrient management systems, focusing on their role in enhancing nutrient availability, uptake efficiency, and overall crop performance. Copper coordination complexes offer unique advantages in agricultural applications due to their ability to stabilize essential nutrients, regulate release rates, and improve bioavailability under varying soil conditions. The integration of these complexes into precision agriculture systems enables targeted nutrient delivery, reduced fertilizer waste, and enhanced crop yields. This comprehensive review analyzes the molecular mechanisms underlying copper-plant interactions, evaluates the effectiveness of different coordination complex formulations, and examines their implementation in modern farming practices. Field studies demonstrate significant improvements in nutrient use efficiency, with copper coordination complexes showing enhanced nitrogen uptake rates of up to 35% compared to conventional fertilizer applications. The technology also demonstrates remarkable potential in addressing micronutrient deficiencies and improving stress tolerance in crops. Environmental benefits include reduced nutrient runoff and improved soil health indicators. Current challenges include cost optimization, stability under field conditions, and integration with existing precision agriculture infrastructure. Future research directions focus on developing smart delivery systems and expanding applications across diverse crop species and growing conditions.
subject: Articles
  topic: section
subject: copper coordination complexes
  topic: keywords
subject: precision agriculture
  topic: keywords
subject: nutrient management
  topic: keywords
subject: fertilizer efficiency
  topic: keywords
subject: crop productivity
  topic: keywords
subject: smart farming
  topic: keywords
creator: Yuting Zhou
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-10-17
publication date: 2025-10-17
starting page: 176
ending page: 185

Coordination Chemistry Approaches to Biological Activity Modulation: Copper Complexes and Enzyme Interactions
type: item
description: Coordination chemistry has emerged as a powerful approach for modulating biological activity through the design and application of metal complexes that interact with enzymatic systems. Copper complexes, in particular, have demonstrated significant potential in biological applications due to their unique redox properties, versatile coordination geometries, and ability to participate in electron transfer processes essential for enzymatic function. This review examines the fundamental principles underlying copper-enzyme interactions, focusing on the mechanisms by which synthetic copper complexes can modulate enzyme activity through coordination chemistry approaches. The investigation encompasses the structural characteristics of copper active sites in biological systems, the design strategies for artificial metalloproteins, and the therapeutic applications of copper complexes as enzyme inhibitors and modulators. Recent advances in multicopper oxidases, urease inhibition, and anticancer applications demonstrate the versatility of coordination chemistry in developing biologically active compounds. The study reveals that copper complexes can serve as both enzyme mimics and inhibitors, depending on their structural features and coordination environment. Understanding these interactions provides valuable insights for the rational design of next-generation therapeutic agents and the development of biomimetic catalysts with enhanced selectivity and efficiency for targeted biological applications.
subject: Articles
  topic: section
subject: coordination chemistry
  topic: keywords
subject: copper complexes
  topic: keywords
subject: enzyme modulation
  topic: keywords
subject: metalloproteins
  topic: keywords
subject: biological activity
  topic: keywords
subject: enzyme inhibition
  topic: keywords
creator: Xinyi Zhang
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-10-16
publication date: 2025-10-16
starting page: 167
ending page: 175

Chemical Modification Strategies for Enhanced Urease Inhibition Activity: Coordination Polymer Optimization Techniques
type: item
description: The development of effective urease inhibitors has emerged as a critical research frontier in combating urease-related pathologies and agricultural challenges. This comprehensive study explores advanced chemical modification strategies for enhancing urease inhibition activity through systematic coordination polymer optimization techniques. The research investigates the structural-activity relationships of metal-organic coordination polymers, focusing on ligand design, metal center selection, and synthetic optimization approaches. Through systematic analysis of coordination environments and their impact on enzyme inhibition mechanisms, this work demonstrates significant improvements in urease inhibition efficacy. The study encompasses detailed examinations of copper-based, manganese-based, and mixed-metal coordination polymers, revealing that strategic chemical modifications can enhance inhibition activity by up to 300% compared to conventional inhibitors. Advanced characterization techniques including X-ray crystallography, spectroscopic analysis, and molecular docking studies provide mechanistic insights into the inhibition processes. The optimization strategies focus on chelation enhancement, dimensional control, and auxiliary ligand incorporation, demonstrating remarkable potential for therapeutic applications against Helicobacter pylori infections and agricultural urease management. These findings establish a comprehensive framework for rational design of next-generation urease inhibitors with superior selectivity and reduced toxicity profiles.
subject: Articles
  topic: section
subject: urease inhibition
  topic: keywords
subject: coordination polymers
  topic: keywords
subject: chemical modification
  topic: keywords
subject: enzyme inhibitors
  topic: keywords
subject: metal-organic frameworks
  topic: keywords
subject: therapeutic applications
  topic: keywords
creator: Bo Wu
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-10-14
publication date: 2025-10-14
starting page: 156
ending page: 166

Adaptive Dose Optimization Algorithm for LED-based Photodynamic Therapy Based on Deep Reinforcement Learning
type: item
description: Current photodynamic therapy fails. Not occasionally-systematically. We measured optical coefficients across 1,847 lesions: peripheral zones exhibit μs' ≈ 20 cm⁻¹ while necrotic zones μs' ≈ 0.8 cm⁻¹, a 25-fold discontinuity that renders uniform protocols obsolete. Drug clearance varies threefold. One patient metabolizes protoporphyrin IX in two hours; another requires six. Oxygen maps tell an equally chaotic story-partial pressures crash from 95 mmHg to anoxic thresholds within minutes, creating dead zones where photochemistry simply stops. We built a system that adapts. Deep reinforcement learning processes 384 physiological signals in real-time, adjusting power density and fractionation schedules every 100 milliseconds. The architecture splits decision-making: one network learns patient baselines, another computes action advantages. This dueling structure stabilizes training on sparse clinical data, where 62.5% of treatments historically achieved only partial or no response. Results contradict decades of conservative practice. Phototoxicity decreased from 18.3% to 7.6%, a relative risk reduction of 58% (95% CI: 49-66%). Complete responses jumped from 37.8% to 58.7%-not through gentler treatment, but through aggressive, precisely-timed interventions the algorithm discovered autonomously. A paradox emerged: lower doses for superficial lesions, intense protocols for deep tumors, opposite to clinical intuition. The system runs on standard GPUs. No specialized hardware. Forty-seven prospective patients confirmed what retrospective analysis suggested: adaptive control fundamentally outperforms fixed protocols.
subject: Articles
  topic: section
subject: deep reinforcement learning
  topic: keywords
subject: LED-based photodynamic therapy
  topic: keywords
subject: adaptive dose control
  topic: keywords
subject: personalized medicine
  topic: keywords
creator: Zonglei Dong
creator: Ruoxi Jia
rights: Copyright (c) 2025 Journal of Sustainability, Policy, and Practice
date: 2025-10-10
publication date: 2025-10-10
starting page: 144
ending page: 155